By targeting various virulence
factors novel therapies can be devised for the treatment of severe infections
caused by Pseudomonas
species. Current therapies focus on the use of antibiotics but the development
of antibiotic resistance and expression of multiple virulence factors has led
to the ineffectiveness of current therapies. The main virulence determinants ofPseudomonasinfections are not only bacterial surface factors, flagella, pili and lipopolysaccharide,
but also active processes such as the secretion of toxins, biofilm formation,
quorum sensing as well as the involvement of swarming-swimming motility,
motility enables P. aeruginosa to colonize different environments,
attach to surfaces, and form biofilms.
P. aeruginosa and P. fluorescens can become resistant to certain
antibiotics which further complicates the treatment of its infections. This
resistance arises due to its ability to form biofilm which consist of bacterial
communities embedded in an exopolysaccharide matrix (EPS). Because of their
high resistance to antimicrobial and cleaning treatments,their biofilms
contribute markedly to the persistence of pathogens on medical devices, leading
to critical problems in terms of public health and a potentially major economic
impact.(Read more)
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